Resurfacing work will start on a section of the Buncrana Road on June 27 and will continue until August 19.
The work will take place from the bottom of the Racecourse Road to Pennyburn Roundabout.
Infrastructure Minister Chris Hazzard confirmed the start of the £160,000 major resurfacing scheme on Thursday.
To facilitate the work a one-way lane closure from 9.30a.m. to 6.00p.m. will be in operation for traffic travelling into the city.
A diversion route via Skeoge Road, Madam’s Bank Road and Culmore Road will be signposted.
A secondary diversion via the Racecourse Road and Greenhaw Road will also be available.
Normal access for city bound traffic will be available prior to 9.30a.m.
A full road closure will be required to enable the final surface layer to be laid on Saturday and Sunday August 6 and 7 and Saturday and Sunday August 13 and 14. The road will be closed from 8.00a.m. to 10.00p.m.
Measures will be put in place to accommodate those attending local places of worship on the Sundays.
“This significant investment will greatly improve the strength and surface quality of the Buncrana Road and address ongoing maintenance problems associated with the road,” said Minister Hazzard.
The planned closures are subject to favourable weather conditions and Transport NI will keep the public informed of any change.
Transport NI says it has carefully programmed the work and traffic management arrangements in order to minimise any inconvenience to the public. However, motorists should be aware that some delays may be expected and that additional time should be allowed when planning any journeys.
For information about this and other improvement schemes across Northern Ireland visit TrafficWatchNI